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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0000000000000298
Brief Report: PDF Only

Low-level Viremia Early in HIV Infection.

Chen, Iris BS; Cummings, Vanessa BS MT (ASCP); Fogel, Jessica M. PhD; Marzinke, Mark A. PhD; Clarke, William PhD; Connor, Matthew B. MS; Griffith, Sam MAT; Buchbinder, Susan MD; Shoptaw, Steven PhD; Rio, Carlos del MD; Magnus, Manya PhD, MPH; Mannheimer, Sharon MD; Wheeler, Darrell P. PhD, MPH, ASCW; Mayer, Kenneth H. MD; Koblin, Beryl A. PhD; Eshleman, Susan H. MD, PhD

Published Ahead-of-Print
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Abstract

HIV RNA levels are usually high early in HIV infection. In the HPTN 061 study, men were tested for HIV infection every six months; six (21.4%) of 28 men who acquired HIV infection during the study had low or undetectable HIV RNA at the time of HIV diagnosis. Antiretroviral drugs were not detected at the time of HIV diagnosis. False-negative HIV test results were obtained for two men using multiple assays. Antiretroviral drug resistance mutations were detected in HIV from one man. Additional studies are needed to identify factors associated with low HIV RNA levels during early HIV infection.

(C) 2014 by Lippincott Williams & Wilkins

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