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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0000000000000228
Original Article: PDF Only

Increase in CD4 Count Among New Enrollees in HIV Care in the Modern Antiretroviral Therapy Era.

Haines, Charles F. M.D.; Fleishman, John A. Ph.D.; Yehia, Baligh R. M.D., M.P.P., M.S.H.P.; Berry, Stephen A. M.D., Ph.D.; Moore, Richard D. M.D., M.H.S.; Bamford, Laura P. M.D., M.S.C.E.; Gebo, Kelly A. M.D., M.P.H.

Published Ahead-of-Print
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Background: Earlier HIV diagnosis and engagement in care improves outcomes and is cost-effective, as a result in 2006 the Centers for Disease Control and Prevention (CDC) revised the HIV screening guidelines. We sought to determine whether the CD4 count (CD4) at presentation, a surrogate for time to presentation, increased during the study period. Our a priori hypothesis was that the CD4 at presentation increased during the study period, particularly after the CDC guideline revision.

Methods: We performed a retrospective cohort study analyzing data from the HIV Research Network (HIVRN), a consortium of 18 US clinics caring for HIV-infected patients. HIV-infected adults (>=18 years old) newly presenting for care between 2003 and 2011 were included in this study. Multivariable linear regression examined associations with CD4 at enrollment. Calendar year was modeled as a linear spline with a change in slope at 2008, allowing determination of the mean change in CD4 per year over the years 2003-07 and 2008-11.

Results: Over 13543 newly presenting subjects enrolled from 2003-11. Median CD4 at enrollment rose from 285 to 317 cells/mm3 between 2003-07 and 2008-11 (p<0.001). After adjusting for age, race/ethnicity, gender, HIV risk factor, and clinic site, the mean increase in CD4 count at presentation per year was 13.3 cells/mm3/year (95% Confidence Interval 6.4-20.1 cells/mm3/year) greater over the years 2008-11 than 2003-07.

Conclusions: We demonstrate a small, but statistically significant increase in CD4 at presentation after the CDC guideline revision. More efforts are needed to decrease time to presentation to HIV care.

(C) 2014 by Lippincott Williams & Wilkins


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