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Brief Report: Association Between Menopause and Unprotected Sex in High-Risk HIV-Positive Women in Mombasa, Kenya

Goyette, Marielle S. MPH; Wilson, Kate S. PhD, MPH; Deya, Ruth MBChB, MPH; Masese, Linnet N. MBChB, MPH, PhD; Shafi, Juma MS; Richardson, Barbra A. PhD, MS; Mandaliya, Kishorchandra MBChB; Jaoko, Walter MD, PhD; McClelland, R. Scott MD, MPH

JAIDS Journal of Acquired Immune Deficiency Syndromes: 15 April 2017 - Volume 74 - Issue 5 - p 488–492
doi: 10.1097/QAI.0000000000001282
Prevention Science

Objective: Many HIV-positive women now live well beyond menopause. Postmenopausal women are no longer at risk for pregnancy, and some studies suggest that they may use condoms less often than premenopausal women. This study tests the hypothesis that, in HIV-positive women who report trading sex for cash or in-kind payment, unprotected sex is more common at postmenopausal visits compared with premenopausal visits.

Design: Prospective cohort study of HIV-positive women ≥16 years old in Mombasa, Kenya.

Methods: At enrollment and monthly follow-up visits, participants completed a standardized interview. Study clinicians collected genital samples at enrollment and quarterly visits. Menopausal status was assessed annually. The primary outcome of unprotected sex was determined by detection of prostate specific antigen (PSA) in vaginal secretions.

Results: This study followed 404 HIV-positive women who contributed 2753 quarterly examination visits. Detection of PSA was less frequent at postmenopausal visits compared with premenopausal visits [55/554, 10.5% versus 394/2199, 17.9%; relative risk (RR) 0.58, 95% confidence interval (CI): 0.39 to 0.87]. Adjusting for age diminished the association between menopause and PSA detection (adjusted RR 0.73, 95% CI: 0.47 to 1.14). At visits where women reported sexual activity in the past week, they reported similar rates of 100% condom use at postmenopausal and premenopausal visits (RR 0.99, 95% CI: 0.87 to 1.13).

Conclusions: In this population of high-risk HIV-positive Kenyan women, postmenopausal status was not associated with a greater risk of unprotected sex. The relationship between menopause and unprotected sex is likely context specific and may differ with varying risk groups, regions, and levels of exposure to sexual health education.

*Department of Epidemiology, University of Washington, Seattle, WA;

Institute of Tropical and Infectious Diseases, University of Nairobi, Nairobi, Kenya;

Department of Medicine, University of Washington, Seattle, WA;

Departments of §Global Health; and

Biostatistics, University of Washington, Seattle, WA.

Correspondence to: Marielle S. Goyette, MPH, Department of Epidemiology, University of Washington, Box 357236, Seattle, WA 98195 (e-mail: mgoyette@uw.edu).

Supported by a grant from the National Institutes of Health (R01 HD72617). Infrastructure and logistical support for the Mombasa research site was provided by the University of Washington's Center for AIDS Research (CFAR), an NIH funded program (P30 AI027757) which is supported by the following centers: NIAID, NCI, NIMH, NIDA, NICHD, NHLBI, and NCCAM.

Presented at the Conference on Retroviruses and Opportunistic Infections; February 25, 2016; Boston, MA.

R.S.M. has received honoraria for invited lectures and consultation as well as donated study product for a trial of treatment of vaginal infections from Embil Pharmaceutical Company. R.S.M. currently receives research funding from Hologic/Gen-Probe for a study of human papilloma virus screening. The remaining authors have no conflicts of interest to disclose.

M.S.G. and R.S.M. designed the study. R.D. and L.N.M. collected the clinical data and conducted participant examinations. J.S. and K.M. conducted and oversaw laboratory procedures. M.S.G. and B.A.R. analyzed the data, and M.S.G. drafted the manuscript. R.S.M. and W.J. provided oversight of study procedures and data collection. All authors contributed to editing of the manuscript and approved submission of the final draft for publication.

Received July 02, 2016

Accepted December 05, 2016

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