Skip Navigation LinksHome > August 1, 2014 - Volume 66 - Issue 4 > A Prospective Cohort Study of the Effect of Depot Medroxypro...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0000000000000187
Brief Report: Epidemiology and Prevention

A Prospective Cohort Study of the Effect of Depot Medroxyprogesterone Acetate on Detection of Plasma and Cervical HIV-1 in Women Initiating and Continuing Antiretroviral Therapy

Day, Summer MD*; Graham, Susan M. MD, MPH, PhD*,†; Masese, Linnet N. MBChB; Richardson, Barbra A. PhD§,‖,¶; Kiarie, James N. MBChB#; Jaoko, Walter MBChB; Mandaliya, Kishorchandra MBChB**; Chohan, Vrasha BSc*,¶; Overbaugh, Julie PhD; Scott McClelland, R. MD, MPH*,†,‡,‖

Collapse Box

Abstract

Abstract: Depot medroxyprogesterone acetate (DMPA) use among HIV-1–infected women may increase transmission by increasing plasma and genital HIV-1 RNA shedding. We investigated associations between DMPA use and HIV-1 RNA in plasma and cervical secretions. One hundred two women initiated antiretroviral therapy, contributing 925 follow-up visits over a median of 34 months. Compared with visits with no hormonal contraception exposure, DMPA exposure did not increase detection of plasma (adjusted odds ratio: 0.81, 95% confidence interval: 0.47 to 1.39) or cervical HIV-1 RNA (adjusted odds ratio: 1.41, 95% confidence interval: 0.54 to 3.67). Our results suggest that DMPA is unlikely to increase infectivity in HIV-positive women who are adherent to effective antiretroviral therapy.

© 2014 by Lippincott Williams & Wilkins

Login

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.