Skip Navigation LinksHome > July 1, 2014 - Volume 66 - Issue 3 > Functionally Defective High-Density Lipoproteins Are Related...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0000000000000160
Brief Report: Basic and Translational Science

Functionally Defective High-Density Lipoproteins Are Related to Heightened T-Cell Activation in Vertically HIV-Infected Adolescents

Sainz, Talía MD*; Ortega-Hernández, Adriana BSc; Serrano-Villar, Sergio MD, PhD; Navarro, María L. MD, PhD§; Rojo, Pablo MD, PhD; Ramos, José T. MD, PhD; Mellado, María J. MD, PhD#; Diaz, Laura PhD*; Alvarez, Maria MD*; Estrada, Vicente MD, PhD**; Gómez-Garre, Dulcenombre PhD; Muñoz-Fernández, María A. MD, PhD*,††

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Abstract

Abstract: We assessed high-density lipoprotein (HDL) anti-inflammatory properties in a cohort of vertically HIV-infected adolescents. We hypothesized that proatherogenic mechanisms related to inflammation and immune activation during HIV infection may impair HDL functionality and impact on the atherosclerotic burden. Compared with healthy controls, HDL from HIV-infected adolescents presented impaired functionality, as determined by its ability to inhibit monocyte chemotaxis in vitro, which correlated with detectable viral loads (P = 0.044), lower CD4 nadir (P = 0.043), increased levels of CD4 T-cell activation (P = 0.018), higher C-reactive protein (P = 0.009), and a tendency toward thicker carotid intima-media thickness (P = 0.071).

© 2014 by Lippincott Williams & Wilkins

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