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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0000000000000104
Brief Report: Basic and Translational Science

Systemic Cytokine Levels Show Limited Correlation With Risk of HIV-1 Acquisition

Lehman, Dara A. MHS, PhD*,†; Ronen, Keshet PhD*; Blish, Catherine A. MD, PhD; Baeten, Jared M. MD, PhD†,§,‖; Jalalian-Lechak, Zahra BS*; Jaoko, Walter MBChB, PhD; Mandaliya, Kishorchandra MBChB, MRCPath#; Richardson, Barbra A. PhD†,**,††; McClelland, R. Scott MD, MPH†,§,‖,¶; Overbaugh, Julie PhD*,‡‡

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Abstract

Abstract: It has been hypothesized that immune activation and inflammation may increase HIV-1 susceptibility, and that cytokines may be useful biomarkers for risk. Within a prospective cohort, we conducted a nested case–control analysis of plasma cytokine levels among women who acquired HIV-1 <3 months after sampling, compared with 3 different control groups. We observed associations between lower interleukin (IL)-6 and IL-10 and higher IL-7 levels with HIV-1 acquisition, however, these associations were inconsistent when comparing with different control groups. Inconsistent results within our study and among previous studies suggest that reproducible findings are needed before cytokines are useful biomarkers for HIV-1 susceptibility.

© 2014 by Lippincott Williams & Wilkins

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