Skip Navigation LinksHome > June 1, 2014 - Volume 66 - Issue 2 > HIV Outcomes in Hepatitis B Virus Coinfected Individuals on...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0000000000000142
Epidemiology and Prevention

HIV Outcomes in Hepatitis B Virus Coinfected Individuals on HAART

Chun, Helen M. MD*; Mesner, Octavio MS*; Thio, Chloe L. MD; Bebu, Ionut PhD*; Macalino, Grace PhD*; Agan, Brian K. MD*; Bradley, William P. MS*; Malia, Jennifer PhD*,‡; Peel, Sheila A. PhD*,‡; Jagodzinski, Linda L. PhD*,‡; Weintrob, Amy C. MD*,§; Ganesan, Anuradha MD*,§; Bavaro, Mary MD*,‖; Maguire, Jason D. MD*,¶; Landrum, Michael L. MD#; the Infectious Disease Clinical Research Program HIV Working Group

Collapse Box


Background: Understanding the impact of hepatitis B virus (HBV) coinfection on HIV outcomes in the highly active antiretroviral therapy (HAART) era continues to be a critical priority given the high prevalence of coinfection and the potential for impaired immunologic, virologic, and clinical recovery.

Methods: Participants from the US Military HIV Natural History Study with an HIV diagnosis on HAART and serologically confirmed HBV infection status at HAART initiation (HI) were classified into 4 HBV infection (HB) groups. HIV virologic, immunologic, and clinical outcomes were evaluated by HB status.

Results: Of 2536 HIV-positive HAART recipients, with HBV testing results available to determine HB status in the HI window, HB status at HI was classified as HB negative (n = 1505; 66%), resolved HB (n = 518; 23%), isolated hepatitis B core antigen (n = 139; 6%), or chronic HB (n = 131; 6%). HIV virologic suppression and failure at 6 months or 1 year were not significantly different by HB status. A significantly faster rate of increase in CD4 cell count during the period between 4 and 12 years was observed for chronic HB relative to HB negative. Chronic and resolved HB were associated with an increased risk of AIDS/death compared with HB-negative individuals (chronic HB—hazard ratio = 1.68, 95% confidence interval: 1.05 to 2.68; resolved HB—hazard ratio = 1.61, 95% confidence interval: 1.15 to 2.25).

Conclusions: HB status did not have a significant impact on HIV virologic outcomes, however, CD4 cell count reconstitution after HI and the risk of an AIDS event or death after HI may be associated with HB status.

© 2014 by Lippincott Williams & Wilkins


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.