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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0000000000000108
Brief Report: Clinical Science

Transmitted Drug Resistance and Antiretroviral Treatment Outcomes in Non-Subtype B HIV-1–Infected Patients in South East Asia

Phanuphak, Praphan MD, PhD*,†; Sirivichayakul, Sunee PhD; Jiamsakul, Awachana MSc; Sungkanuparph, Somnuek MD§; Kumarasamy, Nagalingeswaran MD; Lee, Man Po MD; Sirisanthana, Thira MD#; Kantipong, Pacharee MD**; Lee, Christopher MD††; Kamarulzaman, Adeeba MD‡‡; Mustafa, Mahiran MD§§; Ditangco, Rossana MD‖‖; Merati, Tuti MD¶¶; Ratanasuwan, Winai MD##; Singtoroj, Thida PhD***; Kantor, Rami MD†††

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Abstract

Background: We compared treatment outcomes of transmitted drug resistance (TDR) in patients on fully or partially sensitive drug regimens.

Methods: Factors associated with survival and failure were analyzed using Cox proportional hazards and discrete time conditional logistic models.

Results: TDR, found in 60 (4.1%) of 1471 Asian treatment-naive patients, was one of the significant predictors of failure. Patients with TDR to >1 drug in their regimen were >3 times as likely to fail compared to no TDR.

Conclusions: TDR was associated with failure in the context of non-fully sensitive regimens. Efforts are needed to incorporate resistance testing into national treatment programs.

© 2014 by Lippincott Williams & Wilkins

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