Skip Navigation LinksHome > May 1, 2014 - Volume 66 - Issue 1 > Transmitted Drug Resistance and Antiretroviral Treatment Out...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0000000000000108
Brief Report: Clinical Science

Transmitted Drug Resistance and Antiretroviral Treatment Outcomes in Non-Subtype B HIV-1–Infected Patients in South East Asia

Phanuphak, Praphan MD, PhD*,†; Sirivichayakul, Sunee PhD; Jiamsakul, Awachana MSc; Sungkanuparph, Somnuek MD§; Kumarasamy, Nagalingeswaran MD; Lee, Man Po MD; Sirisanthana, Thira MD#; Kantipong, Pacharee MD**; Lee, Christopher MD††; Kamarulzaman, Adeeba MD‡‡; Mustafa, Mahiran MD§§; Ditangco, Rossana MD‖‖; Merati, Tuti MD¶¶; Ratanasuwan, Winai MD##; Singtoroj, Thida PhD***; Kantor, Rami MD†††

Collapse Box

Abstract

Background: We compared treatment outcomes of transmitted drug resistance (TDR) in patients on fully or partially sensitive drug regimens.

Methods: Factors associated with survival and failure were analyzed using Cox proportional hazards and discrete time conditional logistic models.

Results: TDR, found in 60 (4.1%) of 1471 Asian treatment-naive patients, was one of the significant predictors of failure. Patients with TDR to >1 drug in their regimen were >3 times as likely to fail compared to no TDR.

Conclusions: TDR was associated with failure in the context of non-fully sensitive regimens. Efforts are needed to incorporate resistance testing into national treatment programs.

© 2014 by Lippincott Williams & Wilkins

Login

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.