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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0000000000000086
Clinical Science

Association of Chronic Cough and Pulmonary Function With 6-Minute Walk Test Performance in HIV Infection

Campo, Monica MD, MPH*; Oursler, Krisann K. MD†,‡; Huang, Laurence MD§; Goetz, Matthew Bidwell MD‖,¶; Rimland, David MD#,**; Hoo, Guy Soo MD††; Brown, Sheldon T. MD‡‡,§§; Rodriguez-Barradas, Maria C. MD‖‖,¶¶; Au, David MD, MS*; Akgün, Kathleen M. MD##,***; Shahrir, Shahida MPH*; Crothers, Kristina MD*

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Abstract

Objective: Chronic lung disease has been associated with greater impairment in self-reported physical function in HIV-infected patients. We sought to study this association using objective measures of physical function and pulmonary function.

Design: Baseline data from the Examinations of HIV Associated Lung Emphysema study, a multicenter observational cohort of HIV-infected and uninfected veterans.

Methods: We assessed the association between clinical, laboratory, and pulmonary function measures with 6-minute walk test (6-MWT). Multivariable linear regression models were generated to identify factors associated with 6-MWT performance.

Results: Three hundred forty participants completed 6-MWT (mean age 55 years), with 68% blacks, 94% men, and 62% current smokers. Overall, 180 (53%) were HIV-infected and 63 (19%) had spirometry-defined chronic obstructive pulmonary disease. In a multivariable model, age, current smoking, and obesity (body mass index > 30) were independently associated with lower 6-MWT performance, but HIV infection was not; there was a significant interaction between HIV and chronic cough, such that distance walked among HIV-infected participants with chronic cough was 51.76 m less (P = 0.04) compared with those without cough or HIV. Among HIV-infected participants, the forced expiratory volume in 1 second (FEV1, percent predicted), to a greater extent than total lung capacity or diffusing capacity, attenuated the association with chronic cough; decreased FEV1 was independently associated with lower 6-MWT performance in those with HIV.

Conclusions: Older age, current smoking, and airflow limitation were important determinants of 6-MWT performance in the HIV-infected participants. These findings suggest that potential interventions to improve physical function may include early management of respiratory symptoms and airflow limitation.

© 2014 by Lippincott Williams & Wilkins

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