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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0000000000000092
Brief Report: Basic and Translational Science

HIV Infection Deregulates the Balance Between Regulatory T Cells and IL-2–Producing CD4 T Cells by Decreasing the Expression of the IL-2 Receptor in Treg

Méndez-Lagares, Gema PhD*; Jaramillo-Ruiz, Didiana; Pion, Marjorie PhD; Leal, Manuel MD, PhD*; Muñoz-Fernández, M. A. MD, PhD†,‡; Pacheco, Yolanda M. PhD*; Correa-Rocha, Rafael PhD

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Abstract

Abstract: Indexation of regulatory T cells (Treg) to the number of activated T cells constitutes a homeostatic mechanism ensuring that T-cell expansion remains under control. However, immune hyperactivation observed in HIV-infected patients suggests a possible dysfunction of this mechanism. Here we show that the Treg/IL-2–producing cells' balance is deeply disturbed in viremic HIV-infected patients. We found a lower expression of IL-2 receptor alpha on Treg from viremic patients. We confirmed in vitro that HIV infection of Treg downregulates IL-2 receptor alpha and phosphorylated STAT5. Our results argue for an impaired capacity of Treg to sense the expansion of activated T cells in HIV-infected patients that could contribute to the immune deregulation.

© 2014 by Lippincott Williams & Wilkins

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