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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e3182a97b81
Brief Report: Clinical Science

Performance of 3 Rapid Tests for Discrimination Between HIV-1 and HIV-2 in Guinea-Bissau, West Africa

Hønge, Bo Langhoff MD*,†; Bjarnason Obinah, Magnús Pétur BSc*,†; Jespersen, Sanne MD*,†; Medina, Candida MD; da Silva Té, David MD; José da Silva, Zacarias MD, PhD†,§; Østergaard, Lars MD, PhD, DMSc*; Laursen, Alex Lund MD, PhD, DMSc*; Wejse, Christian MD, PhD*,†,‖; Erikstrup, Christian MD, PhD; for the Bissau HIV Cohort Study Group

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Abstract

Abstract: As HIV-2 is intrinsically resistant to nonnucleoside reverse transcriptase inhibitors, it is mandatory to discriminate between HIV types before initiating antiretroviral treatment. Guinea-Bissau has the world's highest prevalence of HIV-2 and HIV-1/HIV-2 dually infected individuals. We evaluated 3 rapid tests for discrimination between HIV-1, HIV-2, and dual infections among 219 patients from Guinea-Bissau by comparing with the gold standard (INNO-LIA). Genie III HIV-1/HIV-2 was the best performer with regard to discriminatory capacity (agreement 91.8%), followed by Immunoflow HIV1-HIV2 (agreement 90.9%) and SD Bioline HIV-1/2 3.0 (agreement 84.5%). Our results underscore the need for evaluation of tests in relevant populations before implementation.

© 2014 by Lippincott Williams & Wilkins

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