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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e3182a685dc
Brief Report: Clinical Science

Incidence of Hepatocellular Carcinoma in HIV-Infected Patients With Cirrhosis: A Prospective Study

Montes Ramírez, María Luisa MD*; Miró, José M. MD; Quereda, Carmen MD; Jou, Antoni MD§; von Wichmann, Miguel Ángel MD; Berenguer, Juan MD; González-García, Juan J. MD*; Hernando, Asunción MD#; Ortega, Enrique MD**; Sanz, José MD††; Arribas, José R. MD*; GESIDA 3703.FIPSE 36466503–N5 NEAT Study Group

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Abstract

Abstract: This study assesses the incidence of hepatocellular carcinoma (HCC) in a prospective cohort of HIV-infected patients, the majority receiving antiretroviral therapy, with liver cirrhosis from different etiologies, enrolled between 2004 and 2005 with median follow-up of 5 years. We followed 371 patients, 25.6% with decompensated cirrhosis at baseline. The incidence rate of HCC was 6.72 per 1000 person-years [95% confidence interval (CI): 2.6 to 10.9]. There was a trend toward a higher cumulative probability of developing HCC at 6 years of follow-up (considering death and liver transplant as competing risks) in patients with decompensated versus compensated cirrhosis at baseline (6% vs. 2%, P < 0.06).

© 2014 by Lippincott Williams & Wilkins

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