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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e3182a990e2
Brief Report: Basic and Translational Science

ACSM4 Polymorphisms Are Associated With Rapid AIDS Progression in HIV-Infected Patients

Guzmán-Fulgencio, María PhD*; Jiménez, José L. PhD; Jiménez-Sousa, María A. PhD*; Bellón, José M. PhD; García-Álvarez, Mónica PhD*; Soriano, Vicente MD, PhD§; Gijón-Vidaurreta, Paloma MD, PhD; Bernal-Morell, Enrique MD, PhD; Viciana, Pompeyo MD, PhD#; Muñoz-Fernández, M. Ángeles MD, PhD**,††,‡‡; Resino, Salvador PhD*

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Abstract: Our aim was to explore the association among ACSM4 and PECI polymorphisms and AIDS progression in 454 HIV-infected patients never treated with antiretroviral drugs (146 long-term nonprogressors, 228 moderate progressors, and 80 rapid progressors). For ACSM4 polymorphisms, rs7137120 AA/AG and rs7961991 CC/CT genotypes had higher odds of having a rapid AIDS progression [odds ratio (OR) = 3.21; 95% of confidence interval (95% CI) = 1.26 to 8.16; P = 0.014 and OR = 3.60; 95% CI = 1.38 to 9.36; P = 0.009, respectively]. Additionally, the ACSM4 haplotype integrated for both rs7961991 A and rs7137120 C alleles had higher odds of having a rapid AIDS progression (OR = 2.85; 95% CI = 1.28 to 6.25; P = 0.010). For PECI polymorphisms, no significant associations were found. In conclusion, ACSM4 polymorphisms might play a significant role in AIDS progression.

© 2014 by Lippincott Williams & Wilkins


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