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ACSM4 Polymorphisms Are Associated With Rapid AIDS Progression in HIV-Infected Patients

Guzmán-Fulgencio, María PhD*; Jiménez, José L. PhD; Jiménez-Sousa, María A. PhD*; Bellón, José M. PhD; García-Álvarez, Mónica PhD*; Soriano, Vicente MD, PhD§; Gijón-Vidaurreta, Paloma MD, PhD; Bernal-Morell, Enrique MD, PhD; Viciana, Pompeyo MD, PhD#; Muñoz-Fernández, M. Ángeles MD, PhD**,††,‡‡; Resino, Salvador PhD*

JAIDS Journal of Acquired Immune Deficiency Syndromes: 1 January 2014 - Volume 65 - Issue 1 - p 27–32
doi: 10.1097/QAI.0b013e3182a990e2
Brief Report: Basic and Translational Science

Abstract: Our aim was to explore the association among ACSM4 and PECI polymorphisms and AIDS progression in 454 HIV-infected patients never treated with antiretroviral drugs (146 long-term nonprogressors, 228 moderate progressors, and 80 rapid progressors). For ACSM4 polymorphisms, rs7137120 AA/AG and rs7961991 CC/CT genotypes had higher odds of having a rapid AIDS progression [odds ratio (OR) = 3.21; 95% of confidence interval (95% CI) = 1.26 to 8.16; P = 0.014 and OR = 3.60; 95% CI = 1.38 to 9.36; P = 0.009, respectively]. Additionally, the ACSM4 haplotype integrated for both rs7961991 A and rs7137120 C alleles had higher odds of having a rapid AIDS progression (OR = 2.85; 95% CI = 1.28 to 6.25; P = 0.010). For PECI polymorphisms, no significant associations were found. In conclusion, ACSM4 polymorphisms might play a significant role in AIDS progression.

*Unidad de Coinfección HIV/Hepatitis, Centro Nacional de Microbiología, Hospital Carlos III, Madrid, Spain;

Plataforma de Laboratorio, Hospital General Universitario “Gregorio Marañón,” Madrid, Spain;

Fundación para la Investigación Biomédica, Hospital General Universitario “Gregorio Marañón,” Madrid, Spain;

§Servicio de Enfermedades Infecciosas, Hospital Carlos III, Madrid, Spain;

Servicio Microbiología, Hospital General Universitario Gregorio Marañon, Madrid, Spain;

Servicio de Enfermedades Infecciosas, Hospital General Universitario Reina Sofia, Madrid, Spain;

#Servicio de Enfermedades Infecciosas, Hospital Virgen del Rocío, Seville, Spain;

**Laboratorio InmunoBiología Molecular, Hospital General Universitario Gregorio Marañón, Madrid, Spain;

††Instituto de Investigación Sanitaria del Gregorio Marañón, Madrid, Spain; and

‡‡Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.

Correspondence to: Salvador Resino, PhD, Centro Nacional de Microbiología, Instituto de Salud Carlos III (Campus Majadahonda), Carretera Majadahonda-Pozuelo, Km 2.2, 28220 Majadahonda, Madrid, Spain (e-mail: sresino@isciii.es).

Supported by grants given by Fondo de Investigacion de Sanidad en España (Spanish Health Founds for Research) (grant numbers: PI11/00245, PI11-00888, PS09/02029, and PS09/02669), Red Española de Investigación en SIDA (AIDS Research Network) (grant numbers: RD12/0017/0024, RD06/0006/0035, RD12/0017/0037, and RD09/0076/00103), “Fundación para la Investigación y la Prevención del Sida en España” (300509), Comunidad de Madrid (grant numbers: S-2010/BMD-2351 and S-2010/BMD-2332), PENTA, Cost action TD0802, and the “Programa de Investigacion de la Consejeria de Sanidad de la Comunidad de Madrid” to J.L.J. M.G.-F., M.G.-A., and M.A.J.-S. are supported by “Instituto de Salud Carlos III” (grant numbers: CM09/00031, CD12/00442, and CM10/00105, respectively).

The authors have no conflicts of interest to disclose.

V.S., P.G.-V., and E.B.-M.: On behalf of CoRIS and the HIV HGM Biobank integrated in the Spanish AIDS Research Network. P.V.: On behalf of LTNPs Cohort integrated in the Spanish AIDS Research Network.

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Received June 10, 2013

Accepted August 13, 2013

© 2014 by Lippincott Williams & Wilkins