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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e31829f919d
Basic and Translational Science

Microbial Translocation in HIV Infection Is Associated With Dyslipidemia, Insulin Resistance, and Risk of Myocardial Infarction

Pedersen, Karin K. MD*,†; Pedersen, Maria MD, PhD; Trøseid, Marius MD, PhD; Gaardbo, Julie C. MD*; Lund, Tamara T. BSc*; Thomsen, Carsten MD, PhD§; Gerstoft, Jan MD, DMSc*; Kvale, Dag MD, DMSc‡,‖; Nielsen, Susanne D. MD, DMSc*

Supplemental Author Material
Erratum

Erratum

In the article by Pedersen et al., appearing in JAIDS: Journal of Acquired Immune Deficiency Syndromes, Vol. 64, No. 5, pp. 425-433, entitled “Microbial Translocation in HIV Infection Is Associated With Dyslipidemia, Insulin Resistance, and Risk of Myocardial Infarction”, there are two errors that appeared on page 428 in Table 2. The subtitle “Smokers” should have read “Total population” and “Healthy Controls (n=32)” should have read “Healthy Controls (n=31)”.

JAIDS Journal of Acquired Immune Deficiency Syndromes. 66(3):e71, July 1, 2014.

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Abstract

Objective: Microbial translocation has been suggested to be a driver of immune activation and inflammation. It is hypothesized that microbial translocation may be related to dyslipidemia, insulin resistance, and the risk of coronary heart disease in HIV-infected individuals.

Design: Cross-sectional study of 60 HIV-infected patients on combination antiretroviral therapy with viral suppression >2 years and 31 healthy age-matched controls.

Methods: Lipopolysaccharide (LPS) was analyzed by limulus amebocyte lysate colorimetric assay. Lipids, including cholesterol, low-density lipoprotein (LDL), and triglycerides, were measured. Glucose metabolism was determined using an oral glucose tolerance test. Body composition was determined using whole-body dual-energy x-ray absorptiometry scans and magnetic resonance imaging. The Framingham risk score was used to assess risk of cardiovascular disease and myocardial infarction.

Results: HIV-infected patients had higher level of LPS compared with controls (64 pg/mL vs. 50 pg/mL, P = 0.002). Likewise, HIV-infected patients had higher triglycerides, LDL, and fasting insulin as well as evidence of lower insulin sensitivity compared with controls. Among HIV-infected patients, high LPS was associated with a higher level of triglycerides and LDL and with lower insulin sensitivity. Importantly, among HIV-infected patients, high LPS was associated with a higher Framingham risk score.

Conclusions: HIV-infected patients with suppressed viral replication had increased level of microbial translocation as measured by LPS. LPS was associated with cardiometabolic risk factors and increased Framingham risk score. Hence, the gastrointestinal mucosal barrier may be a potential therapeutic target to prevent dyslipidemia and future cardiovascular complications in HIV infection.

© 2013 by Lippincott Williams & Wilkins

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