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Chronic HIV-Infected Patients Show an Impaired Dendritic Cells Differentiation of Bone Marrow CD34+ Cells

Bordoni, Veronica PhD*; Bibas, Michele MD; Viola, Domenico MLT*; Sacchi, Alessandra PhD*; Agrati, Chiara PhD*; Castelli, Germana PhD; Ammassari, Adriana MD; Amendola, Alessandra PhD§; Abbate, Isabella PhD§; Martini, Federico PhD*

JAIDS Journal of Acquired Immune Deficiency Syndromes: December 1st, 2013 - Volume 64 - Issue 4 - p 342–344
doi: 10.1097/QAI.0b013e3182a40ff7
Brief Report: Basic and Translational Science

Abstract: HIV infection affects dendritic cells (DCs) number, maturation, and function although the cause remains largely unknown. Purified CD34+ hematopoietic progenitor cells (HPCs) obtained from bone marrow of chronic HIV-infected patients were investigated for the differentiative capability toward mature DCs. HIV, although not in active replication, was found able to impair CD34+ HPC differentiation into mature DCs. These results suggest that DCs impairment found in HIV-infected patients may be related to a failure by bone marrow CD34+ HPCs to produce an adequate number of DCs.

*Laboratory of Cellular Immunology, National Institute for Infectious Diseases “Lazzaro Spallanzani” I.R.C.C.S., Rome, Italy;

Clinical Department, National Institute for Infectious Diseases “Lazzaro Spallanzani” I.R.C.C.S., Rome, Italy;

Department of Haematology, Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy; and

§Virology Laboratory, National Institute for Infectious Diseases “Lazzaro Spallanzani” I.R.C.C.S., Rome, Italy.

Correspondence to: Veronica Bordoni, PhD, Laboratory of Cellular Immunology, National Institute for Infectious Diseases “Lazzaro Spallanzani” I.R.C.C.S., Via Portuense, 292—00149 Rome, Italy (e-mail: veronica.bordoni@inmi.it).

Supported by Italian Ministry of Health (RF-IMI-2009-1304187 and Programma di Ricerca Corrente IRCCS).

The authors have no conflicts of interest to disclose.

Received May 31, 2013

Accepted July 08, 2013

© 2013 by Lippincott Williams & Wilkins