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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e31829bdc85
Basic and Translational Science

Prevalence of HIV-1 Dual Infection in Long-Term Nonprogressor–Elite Controllers

Pernas, María PhD*; Casado, Concepción PhD*; Sandonis, Virginia PhD*; Arcones, Carolina BSc*; Rodríguez, Carmen PhD; Ruiz-Mateos, Ezequiel PhD; Ramírez de Arellano, Eva PhD§; Rallón, Norma PhD; Del Val, Margarita PhD§,¶; Grau, Eulalia BSc#; López-Vazquez, Mariola PhD; Leal, Manuel MD; Del Romero, Jorge MD; López Galíndez, Cecilio PhD*

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Abstract

Introduction: Human immunodeficiency virus type 1 (HIV-1) dual infection (DI) in long-term nonprogressor–elite controller patients (LTNP-EC) has been described only in sporadic cases and then, consequences in disease progression are not clearly established. To fill-up this limited knowledge, we analyzed, for the first time, the prevalence, host genetic polymorphisms, and clinical consequences of HIV-1 DI in a group of LTNP-EC.

Methods: For DI detection, nucleotide sequences in env gene from viruses from 20 LTNP-EC were analyzed by maximum likelihood. Epidemiological and clinical parameters and host factors of patients were also studied.

Results: DI was detected in 4 (20%) of the 20 LTNP-EC, of which 3 maintained the elite controller status. CD4+ T-cell counts were not different between single and DI patients although higher CD8+ T-cell counts were observed in DI patients, and, consequently, the CD4+/CD8+ ratios were lower in LTNP-EC DI patients.

Conclusions: Prevalence of HIV-1 DIs in LTNP-EC is similar to other groups of HIV-1 patients; in addition, DI was not associated with loss of disease control in the patients. These DI LTNP-EC patients showed, in comparison with single infected patients, higher numbers of CD8+ T cells and lower CD4+/CD8+ ratios.

© 2013 by Lippincott Williams & Wilkins

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