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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e3182a9213a
Brief Report: Clinical Science

HIV Infection Is Associated With Diffusing Capacity Impairment in Women

Fitzpatrick, Meghan E. MD*; Gingo, Matthew R. MD, MS*; Kessinger, Cathy RN*; Lucht, Lorrie BS*; Kleerup, Eric MD; Greenblatt, Ruth M. MD‡,§,‖; Claman, David MD§; Ponath, Claudia MA§; Fong, Serena BS§; Huang, Laurence MD, MAS§; Morris, Alison MD, MS*,¶

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Abstract

Abstract: Respiratory dysfunction is common with HIV infection, but few studies have directly assessed whether HIV remains an independent risk factor for pulmonary function abnormalities in the antiretroviral therapy era. Additionally, few studies have focused on pulmonary outcomes in HIV+ women. We tested associations between risk factors for respiratory dysfunction and pulmonary outcomes in 63 HIV+ and 36 HIV-uninfected women enrolled in the Women's Interagency HIV Study. Diffusing capacity (DLCO) was significantly lower in HIV+ women (65.5% predicted vs. 72.7% predicted, P = 0.01), and self-reported dyspnea in HIV+ participants was associated with both DLCO impairment and airflow obstruction. Providers should be aware that DLCO impairment is common in HIV infection, and that either DLCO impairment or airflow obstruction may cause respiratory symptoms in this population.

© 2013 by Lippincott Williams & Wilkins

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