Skip Navigation LinksHome > November 1, 2013 - Volume 64 - Issue 3 > Early Infection HIV-1 Envelope V1-V2 Genotypes Do Not Enhanc...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e3182a06ddd
Brief Report: Basic and Translational Science

Early Infection HIV-1 Envelope V1-V2 Genotypes Do Not Enhance Binding or Replication in Cells Expressing High Levels of α4β7 Integrin

Etemad, Behzad PhD*; Gonzalez, Oscar A. BS*; McDonough, Sean BS; Pena-Cruz, Victor BS*; Sagar, Manish MD*

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Abstract

Abstract: It has been postulated that HIV-1 envelope properties, such as shorter and less-glycosylated V1-V2 loops commonly observed among non–subtype B early-transmitted viruses, promote utilization of the gut homing integrin α4β7. This property potentially confers an advantage to some HIV-1 variants early after acquisition. We found that replication-competent recombinant viruses incorporating HIV-1 subtype A compact and less-glycosylated early versus chronic phase V1-V2 loops demonstrated no significant difference in binding to α4β7 high CD8+ T cells or replication in α4β7 high CD4+ T cells. Integrin α4β7 usage does not select for shorter less-glycosylated envelopes during transmission.

© 2013 by Lippincott Williams & Wilkins

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