It has been postulated that HIV-1 envelope properties, such as shorter and less-glycosylated V1-V2 loops commonly observed among non–subtype B early-transmitted viruses, promote utilization of the gut homing integrin α4β7. This property potentially confers an advantage to some HIV-1 variants early after acquisition. We found that replication-competent recombinant viruses incorporating HIV-1 subtype A compact and less-glycosylated early versus chronic phase V1-V2 loops demonstrated no significant difference in binding to α4β7 high CD8+ T cells or replication in α4β7 high CD4+ T cells. Integrin α4β7 usage does not select for shorter less-glycosylated envelopes during transmission.
*Department of Medicine, Division of Infectious Disease, Boston University School of Medicine, Boston, MA; and
†Dana Farber Cancer Research Center, Boston, MA.
Correspondence to: Manish Sagar, MD, Boston University School of Medicine, Evans Biomedical Research Center, 650 Albany Street, EBRC-647, Boston, MA 02118-2518 (e-mail: firstname.lastname@example.org).
Supported by National Institute of Health Grant AI1077473 (M.S.).
The authors have no conflicts of interest to disclose.
Received October 19, 2012
Accepted June 13, 2013