Abstract: Individuals infected with HIV type 1 are more likely than noninfected individuals to develop depression. HIV lowers brain-derived neurotrophic factor (BDNF), a neurotrophic factor whose receptors play a crucial role in the pathophysiology of depression. Therefore, we examined whether a single-nucleotide polymorphism in the BDNF gene (rs56164415) and related receptors TrkB (rs1212171) and p75NTR (rs2072446) were associated with depression in HIV-infected individuals. A total of 1365 HIV-positive and 371 HIV-negative female subjects were included. The distribution of alleles was analyzed independently in African Americans (non-Hispanic) and Caucasians (non-Hispanic). We have found that the absence of depressive symptoms in HIV-positive subjects is associated with a genetic variation of the TrkB but not with BDNF or p75NTR genes. This mutation explains 0.8% and 4.4% of the variability for the absence of depression in African Americans and Caucasians, respectively.
Departments of *Neuroscience and
†Medicine, Georgetown University Medical Center, Washington, DC;
‡Departments of Medicine and Epidemiology & Population Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY;
§Departments of Medicine, Stroger Hospital and Rush University, Chicago, IL;
‖Departments of Neurology and Pathology, SUNY Downstate Medical Center, Brooklyn, NY;
¶Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA;
#Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD;
Departments of **Neurology;
††Biostatistics, Bioinformatics, and Biomathematics;
‡‡Psychiatry, Georgetown University Medical Center, Washington, DC; and
§§Collaborative for Research on Outcomes and Metrics, Department of Neurology, Georgetown University Medical Center, Washington, DC.
Correspondence to: Italo Mocchetti, PhD, Department of Neuroscience, Georgetown University Medical Center, New Research Building WP13, 3970 Reservoir Rd, NW, Washington, DC 20057 (e-mail: firstname.lastname@example.org).
Supported by National Institutes of Health (NIH) Grant 1R01-DA026174 to I.M. V.A. is partially supported by a pilot grant through the NIH R25 MH080661 funded program at Johns Hopkins University School of Medicine. Womens’ Interagency HIV Study is funded by NIH Grants UO1-AI-35004, UO1-AI-31834, UO1-AI-34994, UO1-AI-34989, UO1-AI-34993, UO1-AI-42590, UO1-HD-32632, and UL1 RR024131.
The authors have no conflicts of interest to disclose.
Received April 09, 2013
Accepted July 03, 2013