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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e31829f6e41
Brief Report: Basic and Translational Science

Evidence for Efficient Vertical Transfer of Maternal HIV-1 Envelope–Specific Neutralizing Antibodies but No Association of Such Antibodies With Reduced Infant Infection

Omenda, Maxwel M. BSc*,†; Milligan, Caitlin BS*,†,‡; Odem-Davis, Katherine PhD*; Nduati, Ruth MBChB, MMed, MPH§; Richardson, Barbra A. PhD‖,¶,#; Lynch, John MD, MPH*,‡; John-Stewart, Grace MD, MPH, PhD‡,#; Overbaugh, Julie PhD*,**

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Abstract

Abstract: Little is known about the efficiency of vertical transfer of HIV-1–specific antibodies. Antibody levels in plasma from 60 mother–infant pairs near the time of birth, including 14 breast-feeding transmission pairs, were compared. The envelope-binding titers were strongly correlated (r = 0.91, P < 0.0001) and similar (1.4-fold greater in maternal plasma) between a mother and her corresponding infant as were the neutralizing antibody (Nab) levels (r = 0.80, P < 0.0001; 1.3-fold higher), suggesting efficient transfer. There was no significant difference in Nab responses between transmitting and nontransmitting mothers, although there was a trend for transmitting mothers to have higher HIV-1–specific Nabs.

© 2013 by Lippincott Williams & Wilkins

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