Skip Navigation LinksHome > August 1, 2013 - Volume 63 - Issue 4 > Plasma Viremia and Cellular HIV-1 DNA Persist Despite Autolo...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e31828e6163
Brief Report: Basic and Translational Science

Plasma Viremia and Cellular HIV-1 DNA Persist Despite Autologous Hematopoietic Stem Cell Transplantation for HIV-Related Lymphoma

Cillo, Anthony R. BS*; Krishnan, Amrita MD; Mitsuyasu, Ronald T. MD; McMahon, Deborah K. MD*; Li, Shirley MD§; Rossi, John J. PhD; Zaia, John A. MD§; Mellors, John W. MD*

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Abstract

Abstract: A cure of HIV-1 has been achieved in one individual through allogeneic stem cell transplantation with a CCR5[INCREMENT]32 homozygous donor. Whether myeloablation and autologous stem cell transplantation for lymphoma in patients on suppressive antiretroviral therapy can eliminate HIV-1 reservoirs is unknown. Low-level plasma viremia and total HIV-1 DNA and 2-LTR circles in blood mononuclear cells were quantified after autologous transplantation in 10 patients on suppressive antiretroviral therapy using quantitative polymerase chain reaction assays capable of single-copy nucleic acid detection. Plasma viremia was detectable in 9 patients, whereas HIV-1 DNA was detectable in all 10 patients, indicating that HIV-1 had not been eliminated.

© 2013 by Lippincott Williams & Wilkins

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