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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e31828e604b
Brief Report: Basic and Translational Science

Neither Microbial Translocation Nor TLR Responsiveness Are Likely Explanations for Preexisting Immune Activation in Women Who Subsequently Acquired HIV in CAPRISA 004

Naranbhai, Vivek MBChB*,†; Samsunder, Natasha BSc*; Sandler, Netanya G. MD; Roque, Annalys BS; Abdool Karim, Quarraisha PhD*,§; Ndung'u, Thumbi PhD†,‖,¶; Carr, William H. PhD†,‖,#; Altfeld, Marcus MD, PhD†,‖; Douek, Daniel C. MD, PhD; Abdool Karim, Salim S. MBChB, PhD*,§; for The CAPRISA 004 Trial Team

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Abstract

Abstract: Innate immune activation was a strong predictor of HIV acquisition in women at risk for HIV in CAPRISA 004. Identifying the cause(s) of activation could enable targeted prevention interventions. In this study, plasma concentrations of lipopolysaccharide, soluble CD14, and intestinal fatty acid–binding protein did not differ between subjects who did or did not subsequently acquire HIV nor were these levels correlated with plasma cytokines or natural killer cell activation. There was no difference between HIV acquirers and non-acquirers in the chemokine and cytokine responses of peripheral blood mononuclear cells stimulated with TLR2, 4, or 7/8 agonists. Further studies are required.

© 2013 Lippincott Williams & Wilkins, Inc.

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