Abstract: Activation of coagulation pathways may contribute to risk for non–AIDS-related conditions among HIV-positive patients. Tissue factor (TF)–dependent procoagulant activity on circulating microparticles (MP-TF) in the plasma of 163 HIV-positive participants, both untreated and treated, with viral suppression was measured. MP-TF activity was 39% lower among treated versus untreated participants (P < 0.001), which persisted in adjusted models (−36%, P = 0.03). Among treated participants, MP-TF activity correlated modestly with D-dimer (r = 0.24, P = 0.01), von Willebrand factor (r = 0.36, P < 0.001), and interleukin-6 (r = 0.20, P = 0.04) levels. Future research should focus on mechanisms driving residual functional TF activity and whether these alterations have clinical consequences for non–AIDS-defining complications.
*Department of Medicine, University of Minnesota, Minneapolis, MN;
†Department of Medicine, Hennepin County Medical Center, Minneapolis, MN;
‡Division of Biostatistics, University of Minnesota, Minneapolis, MN;
§Department of Medicine, University of North Carolina, Chapel Hill, NC;
Departments of ‖Biochemistry; and
¶Pathology, University of Vermont, Burlington, VA.
Correspondence to: Jason V. Baker, MD, MS, Department of Medicine, Hennepin County Medical Center, 701 Park Avenue, Mail Code G5, Minneapolis, MN 55415 (e-mail: firstname.lastname@example.org).
Supported by NIH 1UL1RR033183, NIH 1KL2RR033182-01, NIH 5 K12 RR023247, AHA 09CRP2230357, and Gilead Pharmaceuticals.
The authors have no conflicts of interest to disclose.
Received January 14, 2013
Accepted March 05, 2013