Skip Navigation LinksHome > July 1, 2013 - Volume 63 - Issue 3 > Circulating Levels of Tissue Factor Microparticle Procoagula...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e3182910121
Brief Report: Clinical Science

Circulating Levels of Tissue Factor Microparticle Procoagulant Activity Are Reduced With Antiretroviral Therapy and Are Associated With Persistent Inflammation and Coagulation Activation Among HIV-Positive Patients

Baker, Jason V. MD, MS*,†; Huppler Hullsiek, Katherine PhD; Bradford, Robert L. BS§; Prosser, Rachel PhD, NP; Tracy, Russell P. PhD‖,¶; Key, Nigel S. MD§

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Abstract: Activation of coagulation pathways may contribute to risk for non–AIDS-related conditions among HIV-positive patients. Tissue factor (TF)–dependent procoagulant activity on circulating microparticles (MP-TF) in the plasma of 163 HIV-positive participants, both untreated and treated, with viral suppression was measured. MP-TF activity was 39% lower among treated versus untreated participants (P < 0.001), which persisted in adjusted models (−36%, P = 0.03). Among treated participants, MP-TF activity correlated modestly with D-dimer (r = 0.24, P = 0.01), von Willebrand factor (r = 0.36, P < 0.001), and interleukin-6 (r = 0.20, P = 0.04) levels. Future research should focus on mechanisms driving residual functional TF activity and whether these alterations have clinical consequences for non–AIDS-defining complications.

© 2013 Lippincott Williams & Wilkins, Inc.


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