Abstract: Antiretroviral therapy (ART) significantly reduced the CD8+ cell noncytotoxic anti-HIV response in 12 HIV-1–infected subjects (P < 0.0001). In separate experiments, CD8+ cells from long-term survivors were cocultured with HIV-infected CD4+ cells using varying concentrations of anti-HIV drugs. The antiviral function of CD8+ cells from 4 of the 14 LTSs was reduced with exposure to 10 μM of nevirapine (P < 0.05). The antiviral activity of CD8+ cells from 2 LTSs was inhibited by 5 μM of zidovudine. These studies indicate that nevirapine and probably zidovudine can inhibit the anti-HIV activity of CD8+ cells and thus could influence the effectiveness of antiretroviral therapy.
*Division of Hematology/Oncology, Department of Medicine, and the
†Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, CA; and the
‡Department of Clinical Pharmacy, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA.
Correspondence to: Dr Jay A. Levy, Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-1270 (e-mail: email@example.com).
Supported by US National Institutes of Health grant AI-056992.
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The authors have no conflicts of interest to disclose.
Received November 08, 2012
Accepted January 23, 2013