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Nevirapine Inhibits the Anti-HIV Activity of CD8+ Cells

Liu, Lianxing PhD*,†; Wang, Lin MS*,†; Huang, Liusheng PhD; Siu, Vincent BS*,†; Teque, Fernando BS*,†; Aweeka, Francesca T. PharmD; Levy, Jay A. MD

JAIDS Journal of Acquired Immune Deficiency Syndromes: June 1st, 2013 - Volume 63 - Issue 2 - p 184–188
doi: 10.1097/QAI.0b013e318289822d
Brief Report: Basic and Translational Science

Abstract: Antiretroviral therapy (ART) significantly reduced the CD8+ cell noncytotoxic anti-HIV response in 12 HIV-1–infected subjects (P < 0.0001). In separate experiments, CD8+ cells from long-term survivors were cocultured with HIV-infected CD4+ cells using varying concentrations of anti-HIV drugs. The antiviral function of CD8+ cells from 4 of the 14 LTSs was reduced with exposure to 10 μM of nevirapine (P < 0.05). The antiviral activity of CD8+ cells from 2 LTSs was inhibited by 5 μM of zidovudine. These studies indicate that nevirapine and probably zidovudine can inhibit the anti-HIV activity of CD8+ cells and thus could influence the effectiveness of antiretroviral therapy.

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*Division of Hematology/Oncology, Department of Medicine, and the

Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, CA; and the

Department of Clinical Pharmacy, San Francisco General Hospital, University of California, San Francisco, San Francisco, CA.

Correspondence to: Dr Jay A. Levy, Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-1270 (e-mail: jay.levy@ucsf.edu).

Supported by US National Institutes of Health grant AI-056992.

Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's Web site (www.jaids.com).

The authors have no conflicts of interest to disclose.

Received November 08, 2012

Accepted January 23, 2013

© 2013 by Lippincott Williams & Wilkins