Skip Navigation LinksHome > June 1, 2013 - Volume 63 - Issue 2 > Nevirapine Inhibits the Anti-HIV Activity of CD8+ Cells
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e318289822d
Brief Report: Basic and Translational Science

Nevirapine Inhibits the Anti-HIV Activity of CD8+ Cells

Liu, Lianxing PhD*,†; Wang, Lin MS*,†; Huang, Liusheng PhD; Siu, Vincent BS*,†; Teque, Fernando BS*,†; Aweeka, Francesca T. PharmD; Levy, Jay A. MD

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Abstract

Abstract: Antiretroviral therapy (ART) significantly reduced the CD8+ cell noncytotoxic anti-HIV response in 12 HIV-1–infected subjects (P < 0.0001). In separate experiments, CD8+ cells from long-term survivors were cocultured with HIV-infected CD4+ cells using varying concentrations of anti-HIV drugs. The antiviral function of CD8+ cells from 4 of the 14 LTSs was reduced with exposure to 10 μM of nevirapine (P < 0.05). The antiviral activity of CD8+ cells from 2 LTSs was inhibited by 5 μM of zidovudine. These studies indicate that nevirapine and probably zidovudine can inhibit the anti-HIV activity of CD8+ cells and thus could influence the effectiveness of antiretroviral therapy.

© 2013 by Lippincott Williams & Wilkins

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