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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e3182893f74
Brief Report: Basic and Translational Science

Mitochondrial Haplogroups Are Associated With Clinical Pattern of AIDS Progression in HIV-Infected Patients

Guzmán-Fulgencio, María PhD*; Jiménez, José Luis PhD; García-Álvarez, Mónica PhD*; Bellón, José María BSc; Fernández-Rodriguez, Amanda PhD*; Campos, Yolanda PhD§; Rodríguez, Carmen PhD; González-Garcia, Juan MD, PhD; Riera, Melchor MD, PhD#; Viciana, Pompeyo MD, PhD**; Muñoz-Fernández, MÁngeles PhD††,‡‡,§§ª; Resino, Salvador PhD*

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Abstract: We performed a cross-sectional study in 469 HIV-infected patients, whose mitochondrial haplogroups were genotyped to study their association with the clinical pattern of AIDS progression. The chance of not having an AIDS progression was 1.45 [95% of confidence interval (CI) = 1.02 to 2.05, P = 0.035) times greater in patients with cluster HV and 1.51 (95% CI = 1.06 to 2.18, P = 0.021) times greater in patients with haplogroup H. However, we only found significant values for haplogroup H (odds ratio = 1.52, 95% CI = 1.01 to 2.32, P = 0.049) in an ordinal logistic regression adjusted by gender, age at HIV infection, intravenous drug users, and hepatitis C virus infection. These data suggest that mitochondrial haplogroups might play a significant role in AIDS progression.

© 2013 by Lippincott Williams & Wilkins


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