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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e31828d69f1
Brief Report: Clinical Science

Hematologic, Hepatic, Renal, and Lipid Laboratory Monitoring After Initiation of Combination Antiretroviral Therapy in the United States, 2000–2010

Yanik, Elizabeth L. ScM*; Napravnik, Sonia PhD, MPH*,†; Ryscavage, Patrick MD; Eron, Joseph J. MD*,†; Koletar, Susan L. MD§; Moore, Richard D. MD, MHS; Zinski, Anne PhD; Cole, Stephen R. PhD*; Hunt, Peter MD#; Crane, Heidi M. MD, MPH**; Kahn, James MD††; Mathews, William C. MD, MPH‡‡; Mayer, Kenneth H. MD§§; Taiwo, Babafemi O. MBBS‖‖; on behalf of the Center for Aids Research Network of Integrated Clinical Systems (CNICS) Cohort Study

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Abstract: We assessed laboratory monitoring after combination antiretroviral therapy initiation among 3678 patients in a large US multisite clinical cohort, censoring participants at last clinic visit, combination antiretroviral therapy change, or 3 years. Median days (interquartile range) to first hematologic, hepatic, renal, and lipid tests were 30 (18–53), 31 (19–56), 33 (20–59), and 350 (96–1106), respectively. At 1 year, approximately 80% received more than 2 hematologic, hepatic, and renal tests consistent with guidelines. However, only 40% received 1 or more lipid tests. Monitoring was more frequent in specific subgroups, likely reflecting better clinic attendance or clinician perception of higher susceptibility to toxicities.

© 2013 by Lippincott Williams & Wilkins


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