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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e31828decf8
Brief Report: Epidemiology and Prevention

Effect of the Levonorgestrel Intrauterine Device on Genital HIV-1 RNA Shedding Among HIV-1–Infected Women Not Taking Antiretroviral Therapy in Nairobi, Kenya

Coleman, Jenell S. MD, MPH*; Mwachari, Christina MBChB, MSc, MPH; Balkus, Jennifer PhD, MPH; Sanguli, Lucy; Muliro, Angela MBChB, MMed; Agnew, Kathy BS§; Coombs, Robert W. MD, PhD, FRCPC; Cohen, Craig R MD, MPH; Hitti, Jane MD, MPH§

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Abstract: The effect of the levonorgestrel-releasing intrauterine device (LNG-IUD) on genital HIV-1 RNA shedding and inflammation among 25 HIV-infected women was evaluated. Blood, endocervical, and cervicovaginal lavage samples were collected from HIV-infected women not taking antiretrovirals before LNG-IUD insertion and 1 month, 3 month, and 6 months thereafter. HIV-1 RNA was quantitated by real-time reverse transcriptase–polymerase chain reaction. Inflammatory markers were measured by enzyme immunoassay. Genital HIV-1 RNA shedding and inflammatory markers did not differ between LNG-IUD placement and month 6, with the exception of interleukin 1β that increased (0.42 log10; 95% confidence interval: 0.10 to 0.75). The LNG-IUD did not increase genital HIV-1 RNA shedding after 6 months of use.

© 2013 by Lippincott Williams & Wilkins


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