Skip Navigation LinksHome > June 1, 2013 - Volume 63 - Issue 2 > Effect of the Levonorgestrel Intrauterine Device on Genital...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e31828decf8
Brief Report: Epidemiology and Prevention

Effect of the Levonorgestrel Intrauterine Device on Genital HIV-1 RNA Shedding Among HIV-1–Infected Women Not Taking Antiretroviral Therapy in Nairobi, Kenya

Coleman, Jenell S. MD, MPH*; Mwachari, Christina MBChB, MSc, MPH; Balkus, Jennifer PhD, MPH; Sanguli, Lucy; Muliro, Angela MBChB, MMed; Agnew, Kathy BS§; Coombs, Robert W. MD, PhD, FRCPC; Cohen, Craig R MD, MPH; Hitti, Jane MD, MPH§

Collapse Box


Abstract: The effect of the levonorgestrel-releasing intrauterine device (LNG-IUD) on genital HIV-1 RNA shedding and inflammation among 25 HIV-infected women was evaluated. Blood, endocervical, and cervicovaginal lavage samples were collected from HIV-infected women not taking antiretrovirals before LNG-IUD insertion and 1 month, 3 month, and 6 months thereafter. HIV-1 RNA was quantitated by real-time reverse transcriptase–polymerase chain reaction. Inflammatory markers were measured by enzyme immunoassay. Genital HIV-1 RNA shedding and inflammatory markers did not differ between LNG-IUD placement and month 6, with the exception of interleukin 1β that increased (0.42 log10; 95% confidence interval: 0.10 to 0.75). The LNG-IUD did not increase genital HIV-1 RNA shedding after 6 months of use.

© 2013 by Lippincott Williams & Wilkins


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.