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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e31828a77f0
Brief Report: Epidemiology and Prevention

Characteristics of B-Cell Lymphomas in HIV/HCV-Coinfected Patients During the Combined Antiretroviral Therapy Era: An ANRS CO16 LYMPHOVIR Cohort Study

Terrier, Benjamin MD, PhD*; Costagliola, Dominique MD, PhD†,‡,§; Prevot, Sophie MD, PhD‖,¶; Chavez, Houria MD, PhD#,**; Missy, Pascale‡,§; Rince, Patricia MD¶,#; Costello, Regis MD, PhD††; Escaut, Lelia MD‡‡; Gabarre, Jean MD§§; Joly, Bertrand MD‖‖; Letranchant, Lorraine MD, PhD¶¶; Le Gouill, Steven MD, PhD##; Morineau-Le Houssine, Pascale MD***; Simon, Anne MD; Canioni, Danielle MD, PhD†††; Hermine, Olivier MD, PhD‡‡‡; Cacoub, Patrice MD, PhD*; Taoufik, Yassine MD, PhD¶,#,**; Raphael, Martine MD, PhD¶,#,§§§; Besson, Caroline MD, PhD¶,#,**

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Abstract

Abstract: Hepatitis C virus (HCV) infection is frequent among HIV-infected patients. We describe, the characteristics of 6 HIV/HCV-coinfected patients with B-cell non–Hodgkin lymphoma (NHL) included in a prospective cohort study of HIV-related lymphomas. Five of the 6 cases had features of marginal zone/lymphoplasmacytic NHL versus 1 of 33 HIV only–infected patients. Remarkably, anti-HCV treatment led to a hematological response in a patient with splenic marginal zone lymphoma. This supports the role of chronic antigenic stimulation by HCV on lymphomagenesis and further evaluation of HCV antiviral therapy in coinfected patients with NHL.

© 2013 by Lippincott Williams & Wilkins

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