Skip Navigation LinksHome > May 1, 2013 - Volume 63 - Issue 1 > Immune Recovery After Starting ART in HIV-Infected Patients...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e318288b39d
Brief Report: Epidemiology and Prevention

Immune Recovery After Starting ART in HIV-Infected Patients Presenting and Not Presenting With Tuberculosis in South Africa

Schomaker, Michael Dr. rer. nat, Dipl. Stat*; Egger, Matthias MD, MSc, FFPH; Maskew, Mhairi MBBCh, MSc (Med); Garone, Daniela MD§; Prozesky, Hans MBChB, M Med(Int); Hoffmann, Christopher J. MD, MPH¶,#; Boulle, Andrew MBChB, MSc, PhD*; Fenner, Lukas MD, MSc†,**,††; for IeDEA Southern Africa

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Abstract: We studied the immune response after starting antiretroviral treatment (ART) in 15,646 HIV-infected patients with or without tuberculosis (TB) at presentation in 3 ART programs in South Africa between 2003 and 2010. Patients presenting with TB had similar increases in CD4 cells compared with all other patients (adjusted difference 4.9 cells/µL per 6 months, 95% confidence interval: 0.2 to 9.7). Younger age, advanced clinical stage, female sex, and lower CD4 cell count at ART start were all associated with steeper CD4 slopes. In South Africa, HIV-infected patients presenting with TB experience immune recovery after starting ART that is no worse than in other patients.

© 2013 Lippincott Williams & Wilkins, Inc.


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