Skip Navigation LinksHome > April 2013 - Volume 62 - Issue > D109 The role of Siglec in HIV infection.
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/01.qai.0000429237.09287.58
Abstracts: PDF Only

D109 The role of Siglec in HIV infection.

Zou, Zhongcheng; Chastain, Ashley; Moir, Susan; Cicala, Claudia; Crocker, Paul; Arthos, James; Sun, Peter D.

Collapse Box

Abstract

Using both solution and cell surface binding experiments, we showed that R5- and X4-tropic HIV-1 gp120 proteins recognized a family of I-type lectin receptors, the Sialic acid-binding immunoglobulin-like lectins (Siglec). The recognition was through envelope-associated sialic acids that promoted viral adhesion to macrophages. The sialic acid-mediated viral-host interaction facilitated both R5-tropic pseudovirus and HIV-1BaL infection of macrophages. The high affinity Siglec-1 contributed the most to HIV-1 infection and the variation in Siglec-1 expression on primary macrophages from different donors was associated statistically with sialic acid-facilitated viral infection. Furthermore, envelope-associated sialoglycan variations on various strains of R5-tropic viruses also affected infection. This glycan-mediated viral adhesion underscores the importance of viral sialic acids in HIV infection and pathogenesis, and suggests a novel class of antiviral compounds targeting Siglec receptors.

(C) 2013 Lippincott Williams & Wilkins, Inc.

Login