Skip Navigation LinksHome > September 1, 2012 - Volume 61 - Issue 1 > Cervical Human Papillomavirus Infection and Shedding of Huma...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e31826327a0
Brief Report: Clinical Science

Cervical Human Papillomavirus Infection and Shedding of Human Immunodeficiency Virus in Cervicovaginal Fluids: a Cross-Sectional Study

Fornabaio, Chiara MD*; Carvalho, Anna C.C. MD, PhD*; Lillo, Flavia MD; Fiore, José R. MD; Bergamaschi, Viviana MD*; Bigoni, Sara MD*; Puzzi, Petra R. MD*; Cristini, Graziella MD*; Comelli, Mario MSc§; Parisi, Maria R. MD; Matteelli, Alberto MD*

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Abstract: We evaluated the association between human papillomavirus cervical infection and HIV shedding in cervicovaginal lavage fluid (CVL), studying 89 HIV-infected women recruited at the Department of Infectious Diseases of Brescia (Italy). HIV shedding in CVL was found in a similar proportion of women with (30%; 21/70) and without (31.6%; 6/19) cervical human papillomavirus infection. A statistically significant correlation was found between HIV viral load in serum and CVL among the 27 women with detectable HIV in CVL (r = 0.4; P = 0.04). However, women on highly active antiretroviral therapy were more likely to have detectable HIV-RNA in CVL despite negative viremia (80% vs. 8%; P < 0.005).

© 2012 Lippincott Williams & Wilkins, Inc.


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