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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e3182567a35
Brief Report: Clinical Science

Steady-State Pharmacokinetics of Lopinavir Plus Ritonavir When Administered Under Different Meal Conditions in HIV-Infected Ugandan Adults

Lamorde, Mohammed MBBS, MRCP*,†; Byakika-Kibwika, Pauline MBChB, MSc, MMed*,†,‡; Boffito, Marta PhD§; Nabukeera, Lillian MBChB*; Mayito, Jonathan MBChB*; Ogwal-Okeng, Jasper MBChB, PhD; Tjia, John PhD; Back, David PhD; Khoo, Saye FRCP; Ryan, Mairin PhD; Merry, Concepta PhD, FRCPI*,†,‡,#

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Abstract: We investigated the effect of food on the steady-state pharmacokinetics of lopinavir and ritonavir in 12 Ugandan patients receiving lopinavir coformulated with ritonavir (LPV/r) tablets using a crossover design. Intensive pharmacokinetic sampling was performed 7 days apart after LPV/r dosing under moderate fat, high fat, and fasted meal conditions. Lopinavir and ritonavir concentrations were determined by liquid chromatography and tandem mass spectrometry. Compared with the fasted state, a high fat meal reduced lopinavir and ritonavir area under the curve by 14% and 29%, respectively. With a moderate fat meal, area under the curve for both drugs was similar to the fasted state.

© 2012 Lippincott Williams & Wilkins, Inc.


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