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Ectopic Fat is Linked to Prior Cardiovascular Events in Men With HIV

Gabriella, Orlando PhD, MD*; Giovanni, Guaraldi MD*; Stefano, Zona MD*; Federica, Carli MD*; Pietro, Bagni MD*; Marianna, Menozzi MD*; Stefania, Cocchi PhD, MD*; Riccardo, Scaglioni MD; Guido, Ligabue MD; Paolo, Raggi PhD, MD

JAIDS Journal of Acquired Immune Deficiency Syndromes: April 15th, 2012 - Volume 59 - Issue 5 - p 494–497
doi: 10.1097/QAI.0b013e31824c8397
Brief Report: Clinical Science

Abstract: Epicardial Adipose Tissue (EAT) has been associated with adverse cardiovascular events in the general population. We studied the association of general adiposity measures (body mass index, waist circumference) and ectopic adipose tissue [visceral adipose tissue (VAT); liver fat (LF); EAT) with prevalent cardiovascular disease (CVD) (prior myocardial infarction, coronary revascularization, stroke, peripheral vascular disease] in 583 HIV-infected men. VAT, EAT, and LF (liver/spleen attenuation ratio < 1.1) were measured by computed tomography. Patients' mean age was 48.5 ± 8.1 years, prior CVD was present in 33 (5.7%) patients. Factors independently associated with CVD on multivariable analyses were age [incidence-rate ratio (IRR) = 1.07, 95% confidence interval (CI): 1.02 to 1.12], smoking (IRR = 2.70, 95% CI: 1.22 to 6.01), Center for Disease Control group C (IRR = 3.09, 95% CI: 1.41 to 6.76), EAT (IRR = 1.13, 95% CI: 1.04 to 1.24, per 10 cm3), LF (IRR = 1.17, 95% CI: 1.04 to 1.32), and VAT (IRR = 1.05, 95% CI: 1.00 to 1.10, per 10 cm3). Ectopic fat but not general adiposity measures were associated with prevalent CVD in men with HIV.

*Department of Medicine and Medical Specialties, University of Modena and Reggio Emilia, Modena, Italy

Department of Imaging, University of Modena and Reggio Emilia, Modena, Italy

Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA

Correspondence to: Guaraldi Giovanni, MD, Dipartimento di Mdedicine e Specialità Mediche, Università di Modena e Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy (e-mail:

The authors have no funding or conflicts of interest to disclose.

Received November 2, 2011

Accepted January 17, 2012

© 2012 Lippincott Williams & Wilkins, Inc.