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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e3182364513
Brief Report: Basic and Translational Science

Improved Viral Suppression After Treatment Optimization in HIV-Infected Patients With Persistent Low-Level Viremia

McConnell, Michael J. MD, PhD*; Mier-Mota, Julian BS*; Flor-Parra, Fernando BS*; Martinez-Fernandez, Francisco J.*; Lopez-Cortes, Luis F. MD, PhD*; Viciana, Pompeyo MD, PhD*; Fernandez-Cuenca, Felipe PhD; Perez-Romero, Pilar PhD*

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Abstract

Abstract: Optimizing treatment for patients with persistent low-level viremia is complicated because most genotyping tests are validated for viral loads >1000 copies per milliliter. In this study, genotypes of 92 treatment-experienced patients with persistent low-level viremia were determined using an in-house assay. Based on the resistance profiles obtained from genotyping and patient pharmacologic history, patients were either maintained on their antiviral regimen (n = 51) or received an optimized regimen (n = 41). In the group receiving optimized treatment, undetectable viral loads were achieved in 73.2% at 6 months and at 90.2% at 1 year, indicating that treatment guided by genotyping of patients with low-level viremia is effective in achieving viral suppression.

© 2011 Lippincott Williams & Wilkins, Inc.

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