Skip Navigation LinksHome > November 1, 2011 - Volume 58 - Issue 3 > Genotypic Resistance at Viral Rebound Among Patients Who Rec...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e3182278c29
Brief Report: Clinical Science

Genotypic Resistance at Viral Rebound Among Patients Who Received Lopinavir/Ritonavir-Based or Efavirenz-Based First Antiretroviral Therapy in South Africa

Dlamini, J. Nomthandazo MBBCh*; Hu, Zonghui PhD; Ledwaba, Johanna MS; Morris, Lynn DPhil; Maldarelli, Frank M. MD, PhD§; Dewar, Robin L. PhD; Highbarger, Helene C. MS; Somaroo, Harsha MBBCh; Sangweni, Phumelele BSc(Hon)#; Follmann, Dean A. PhD; Pau, Alice K. PharmD; Phidisa II Study Team

Collapse Box


Abstract: Nonnucleoside reverse transcriptase inhibitor–drug resistance mutations (DRM) are increasingly reported in Africans failing their first antiretroviral regimen. The Phidisa II trial randomized treatment-naive participants to lopinavir/ritonavir or efavirenz with stavudine + lamivudine or zidovudine + didanosine. We report the prevalence of DRM in subjects who achieved HIV RNA <400 copies per milliliter at 6 months, but subsequently had 2 consecutive HIV RNA >1000 copies per milliliter. Sixty-eight participants fulfilled the inclusion criteria. nonnucleoside reverse transcriptase inhibitor–DRM were found in 17 of 36 (47.2%) efavirenz recipients, and M184V/I mutation in 14 of 40 (35.0%) lamivudine recipients. No protease inhibitor mutation was identified in 38 lopinavir/ritonavir recipients. This is one of the first studies in Africa confirming the paucity of protease inhibitor–associated DRM despite virologic failure.

© 2011 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.