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Dyslipidemia in an HIV-Positive Antiretroviral Treatment-Naive Population in Dar es Salaam, Tanzania

Armstrong, Catharina MD*; Liu, Enju PhD*; Okuma, James MS*; Spiegelman, Donna ScD*; Guerino, Chalamilla MD; Njelekela, Marina MD; Grinspoon, Steve MD; Fawzi, Wafaie MBBS, MPH, DrPH*; Hawkins, Claudia MD, MPH†§

JAIDS Journal of Acquired Immune Deficiency Syndromes: June 1st, 2011 - Volume 57 - Issue 2 - p 141-145
doi: 10.1097/QAI.0b013e318219a3d1
Brief Report: Clinical Science

Limited data are available on dyslipidemia in HIV-infected patients in resource-limited settings. We performed a cross-sectional analysis in antiretroviral therapy (ART)-naive, non-fasting HIV-infected patients in Tanzania between November 2004 to June 2008. Robust linear regression modeling was performed. Lipid parameters were assessed in 12,513 patients [65% women; median (interquartile range) age, 36 (30-42) years; CD4 count, 143 (51-290) cells/mm3]. Low high-density lipoprotein was prevalent in 67% and increased triglyceride in 28%. High triglyceride and low high-density lipoprotein levels were associated with low CD4 counts (P < 0.001). In this ART-naive Tanzanian population, dyslipidemia was highly prevalent and associated with advanced disease. The impact of ART on these changes requires further exploration.

From the *Harvard School of Public Health, Department of Nutrition, Boston, MA; †Management and Development for Health HIV/AIDS Care and Treatment Program, Dar es Salaam, Tanzania; and ‡Harvard Medical School, Boston, MA; §Northwestern University, Feinberg School of Medicine, Infectious Disease Department, Chicago, IL.

Received for publication December 8, 2010; accepted March 9, 2011.

Supported by the National Institutes of Health [NIH T32, #HD052961-04, K24 DK064545-08] and the Presidents Emergency Plan for AIDS Relief.

Presented at the following meetings: XVIII International AIDS Conference, “Dyslipidemia in an HIV-positive, antiretroviral naive population in Dar es Salaam, Tanzania”, July 21, 2010, Vienna, Austria, Poster WEPE0063; 47th Infectious Disease Society of America (IDSA), “Dyslipidemia in an HIV-positive, antiretroviral naive population in Dar es Salaam, November 30, 2009, Tanzania” Philadelphia, PA, Poster #365; Center for AIDS Research 9th Annual Conference Harvard Medical School, “Dyslipidemia in an HIV-positive, antiretroviral naive population in Dar es Salaam, June 24, 2009, Tanzania” Boston, MA, Poster #27.

All authors played a role in editing the article and approved the text as submitted to JAIDS. C.A. designed the study and wrote the article. E.L. and J.O. performed the data analysis and assisted in the interpretation of statistical data. C.H., S.G., W.F., D.S., C.G., and M.N. reviewed and edited the article.

The authors have no conflicts of interest to disclose.

Correspondence to: Catharina Armstrong, MD, Harvard School of Public Health, Building 2, Room 304, 665 Huntington Ave, Boston, MA 02115 (e-mail: carmstr2@bidmc.harvard.edu).

© 2011 Lippincott Williams & Wilkins, Inc.