Skip Navigation LinksHome > May 1, 2011 - Volume 57 - Issue 1 > Prevalence and Clinical Associations of CXCR4-Using HIV-1 Am...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e318214fe27
Brief Report: Clinical Science

Prevalence and Clinical Associations of CXCR4-Using HIV-1 Among Treatment-Naive Subtype C-Infected Women in Botswana

Lin, Nina H MD*†; Smeaton, Laura M MS§∥; Giguel, Françoise*‡; Novitsky, Vladimir PhD§‖; Moyo, Sikhulile MS‖; Mitchell, Rebecca M PhD§‖; Makhema, Joseph MDChB‖; Essex, Myron PhD, DVM§‖; Lockman, Shahin MD, MSc†‡§‖; Kuritzkes, Daniel R MD†‡

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HIV-1 coreceptor use was determined using a phenotypic assay in plasma samples from treatment-naive women infected with subtype C virus who had CD4 cell counts below 200 cells/mm3. Of 148 women, 14.9% were infected with dual/mixed virus; the remainder had R5 virus. A greater proportion of women in the lowest CD4 cell count stratum had dual/mixed virus (P = 0.026); change in coreceptor use after antiretroviral therapy exposure was uncommon. CXCR4-using HIV-1 was less common in subtype C-infected women than reported in subtype B cohorts but was most prevalent in women with the lowest CD4 cell counts.

© 2011 Lippincott Williams & Wilkins, Inc.


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