Skip Navigation LinksHome > May 1, 2011 - Volume 57 - Issue 1 > Prevalence and Clinical Associations of CXCR4-Using HIV-1 Am...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e318214fe27
Brief Report: Clinical Science

Prevalence and Clinical Associations of CXCR4-Using HIV-1 Among Treatment-Naive Subtype C-Infected Women in Botswana

Lin, Nina H MD*†; Smeaton, Laura M MS§∥; Giguel, Françoise*‡; Novitsky, Vladimir PhD§‖; Moyo, Sikhulile MS‖; Mitchell, Rebecca M PhD§‖; Makhema, Joseph MDChB‖; Essex, Myron PhD, DVM§‖; Lockman, Shahin MD, MSc†‡§‖; Kuritzkes, Daniel R MD†‡

Collapse Box

Abstract

HIV-1 coreceptor use was determined using a phenotypic assay in plasma samples from treatment-naive women infected with subtype C virus who had CD4 cell counts below 200 cells/mm3. Of 148 women, 14.9% were infected with dual/mixed virus; the remainder had R5 virus. A greater proportion of women in the lowest CD4 cell count stratum had dual/mixed virus (P = 0.026); change in coreceptor use after antiretroviral therapy exposure was uncommon. CXCR4-using HIV-1 was less common in subtype C-infected women than reported in subtype B cohorts but was most prevalent in women with the lowest CD4 cell counts.

© 2011 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.