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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e318204a1c3
Rapid Communication

Pandemic (H1N1) 2009 Influenza Virus Seroconversion Rates in HIV-Infected Individuals

Kok, Jen MBBS*; Tudo, Katherine BMedSci*; Blyth, Christopher C MBBS, FRACP, FRCPA†; Foo, Hong MBBS, FRACP, FRCPA‡; Hueston, Linda BSci, MSci*; Dwyer, Dominic E MD, FRACP, FRCPA*

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The impact of pandemic (H1N1) 2009 influenza in HIV-infected individuals is unknown. Determining the prevalence of pandemic influenza in this at-risk group will guide vaccination programs. After the first pandemic wave, the seroprevalence rate of pandemic influenza in HIV-infected individuals in western Sydney, New South Wales, Australia, was 34.2%, similar to the rate observed in the general population. However, true seroprevalence is more accurately determined by seroconversion, defined as a 4-fold or greater rise between preexposure and postexposure antibody levels, which was 14.6% in the present study. Seroconversion rates were independent of CD4+ T-lymphocyte count and HIV plasma load. Neither HIV infection, nor severe immunosuppression, was a significant risk factor for pandemic influenza during the first southern hemisphere pandemic wave.

© 2011 Lippincott Williams & Wilkins, Inc.


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