Skip Navigation LinksHome > December 2009 - Volume 52 - Issue 5 > CD14highCD16+ Rather Than CD14lowCD16+ Monocytes Correlate W...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e3181c1d4fe
Basic Science

CD14highCD16+ Rather Than CD14lowCD16+ Monocytes Correlate With Disease Progression in Chronic HIV-Infected Patients

Han, Junyan MSc*†; Wang, Beibei PhD*†; Han, Ning MD†; Zhao, Yan MD‡; Song, Chuan BSc*; Feng, Xin BSc*; Mao, Yu MD*; Zhang, Fujie MD, MPH†‡; Zhao, Hongxin MD, MPH†; Zeng, Hui MD, PhD*†

Collapse Box


Objective: CD14+CD16+ monocytes are an important cellular target for HIV-1 entry and expand in the peripheral blood of HIV-infected individuals. Because CD14+CD16+ monocytes are a heterogeneous population and consist of CD14highCD16+ and CD14lowCD16+ subsets, we evaluated the effects of HIV infection on distinct subsets of CD16+ monocytes.

Methods: Untreated HIV-infected patients were recruited to investigate the relationship between the proportions of monocyte subsets with plasma viral loads and CD4+ T-cell counts. Patients receiving highly active antiretroviral therapy (HAART) were followed up in a cross-sectional and a longitudinal study.

Results: Compared with CD14lowCD16+, CD14highCD16+ monocytes showed higher levels of CD64 and HLA-DR antigens, which imply that these 2 distinct subsets have different immunoregulatory phenotypes. In HAART-naive patients, elevated proportions of CD14highCD16+ monocytes were correlated with increased viral loads and decreased CD4+ T-cell counts, whereas CD14lowCD16+ monocytes did not show such correlation with disease progression. Of importance, HAART recovered the proportion of CD14highCD16+ monocytes, whereas CD14lowCD16+ monocytes did not decrease during 1 year of antiviral therapy.

Conclusions: Taken together, our observations elucidate distinct immune responses of monocyte subsets during HIV infection and antiviral therapy and provide new insight into the roles of innate immunity in HIV-related pathogenesis.

© 2009 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.