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JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/QAI.0b013e31817bbbf0
Clinical Science

Antiretroviral Therapy is Associated With an Atherogenic Lipoprotein Phenotype Among HIV-1-Infected Men in the Multicenter AIDS Cohort Study

Riddler, Sharon A MD, MPH*; Li, Xiuhong MAS†; Otvos, James PhD‡; Post, Wendy MD, MS†; Palella, Frank MD§; Kingsley, Lawrence Dr.P.H*; Visscher, Barbara MD, Dr.P.H‖; Jacobson, Lisa P ScD†; Sharrett, A R MD, Dr.P.H.†

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Abstract

Background: Alterations in serum lipids and an increased risk of myocardial infarction have been associated with HIV-1 infection and its treatment.

Methods: Lipoprotein subclasses were measured by nuclear magnetic resonance spectroscopy in frozen plasma samples from participants in the Multicenter AIDS Cohort Study. The effects of HIV-1 infection, antiretroviral therapy, and other factors on median particle concentrations were examined using quantile regression.

Results: Fasted samples were tested from 1082 men, including 609 HIV-seronegative and 473 HIV-1-infected men. Compared with HIV-seronegative men, HIV-1-infected men on antiretroviral therapy had an atherogenic phenotype with higher numbers of very low density lipoprotein and small low-density lipoprotein particles and lower numbers of high-density lipoprotein and large low-density lipoprotein particles. HIV-infected, antiretroviral-naive men had significantly lower high-density lipoprotein and small low-density lipoprotein particle concentrations compared with the HIV-seronegative men. Among men on antiretroviral therapy, the atherogenic phenotype was most pronounced in men with a good clinical status.

Conclusion: Use of antiretroviral therapy in HIV-1-infected men was associated with an “atherogenic lipoprotein phenotype.”

© 2008 Lippincott Williams & Wilkins, Inc.

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