Skip Navigation LinksHome > October 1, 2006 - Volume 43 - Issue 2 > Upregulation of Interferon-α and RANTES in the Cervix of HIV...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
doi: 10.1097/01.qai.0000229016.85192.60
Basic Science

Upregulation of Interferon-α and RANTES in the Cervix of HIV-1-Seronegative Women With High-Risk Behavior

Hirbod, Taha BSc*; Nilsson, Jakob MD†; Andersson, Sonia MD, PhD‡; Uberti-Foppa, Caterina MD§; Ferrari, Davide MD‖; Manghi, Mara MD¶; Andersson, Jan MD, PhD†; Lopalco, Lucia PhD#; Broliden, Kristina MD, PhD*

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Abstract

Objective: The expression of innate immune molecules associated with potential blocking activity of HIV-1 propagation was analyzed in the cervical tissue of a group of African HIV-1 IgG-negative commercial sex workers (CSWs) with an HIV-1-encountering risk behavior.

Methods: Cervical biopsies from the superior portion of the ectocervix were assessed for innate immune molecules and evaluated in situ by computerized image analysis at the single-cell level.

Results: A higher expression of interferon-α (IFNα) and RANTES was detected in CSWs and HIV-1-infected individuals as compared to low-risk HIV-1-uninfected controls (Neg Ctrls). Most (>90%) of RANTES-expressing cells were CD8+ cells as determined by confocal microscopy. In contrast, the expression of leukemia inhibitory factor (LIF) and secretory leukocyte protease inhibitor (SLPI) was comparable between the groups. The expression of β-defensin 2 was highest in HIV-1-infected individuals.

Conclusions: Induction of IFNα and RANTES expression in cervical mucosa may contribute to protection of sexual HIV-1 transmission in subjects with a higher risk behavior.

© 2006 Lippincott Williams & Wilkins, Inc.

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