Skip Navigation LinksHome > April 15, 2004 - Volume 35 - Issue 5 > Human α Defensin in HIV-Exposed But Uninfected Individuals
JAIDS Journal of Acquired Immune Deficiency Syndromes:
Basic Science

Human α Defensin in HIV-Exposed But Uninfected Individuals

Trabattoni, Daria BS*; Caputo, Sergio Lo MD†; Maffeis, Giada BS*; Vichi, Francesca MD†; Biasin, Mara BS*; Pierotti, Piera BS†; Fasano, Francesca BS*; Saresella, Marina BS‡; Franchini, Mario MD§; Ferrante, Pasquale MD‡; Mazzotta, Francesco MD†; Clerici, Mario MD*

Collapse Box


Abstract: Human α defensins 1, 2, and 3 are produced by CD8+ T cells of HIV-infected long-term nonprogressors and have an antiviral activity. α Defensins were examined in peripheral blood mononuclear cells (PBMCs), cervical-vaginal mononuclear cells (CVMCs), and cervical biopsies of 9 HIV-1-exposed but uninfected women (ESNs), 10 HIV-infected patients (HIV), and 13 low-risk healthy controls (HCs). Results showed that, whereas α defensin production and α defensin-expressing CD8 lymphocytes were comparable in ESNs and HIV patients, constitutive α defensin production by peripheral CD8 and CVMCs was augmented in ESNs compared with HCs (P = 0.001 and P = 0.058, respectively); α defensin mRNA was increased in PBMCs of ESNs; unstimulated, α defensin-expressing peripheral and mucosal CD8 lymphocytes were 10-fold higher in ESNs compared with HCs (P = 0.003 and P = 0.01, respectively); and α defensin mRNA and α defensin-expressing cells were augmented in cervical biopsies of ESN compared with HCs (mRNA:P = 0.03). The differences were reduced upon in vitro mitogen stimulation. A robust constitutive production of α defensin is seen in HIV-exposed uninfected individuals; these peptides could have a role in the potentially protective immune response that characterizes ESNs.

© 2004 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.