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Reanalysis of the HIV-1 Circulating Recombinant Form A/E (CRF01_AE): Evidence of A/E/G Recombination

Magiorkinis, Gkikas; Paraskevis, Dimitris; Magiorkinis, Emmanouil; Vandamme, Anne-Mieke; Hatzakis, Angelos
JAIDS Journal of Acquired Immune Deficiency Syndromes: May 1st, 2002
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Circulating recombinant form (CRF) 01_AE caused an extensive HIV-1 epidemic in Thailand and Southeast Asia. Reanalysis of the recombination pattern of CRF01_AE suggested a more complicated pattern of mosaicism consisting of subtypes A, G, and E. These findings provide evidence that CRF01_AE originated from recombination between at least three different subtypes.

Address correspondence and reprint requests to A. Hatzakis, National Retrovirus Reference Center, Department of Hygiene and Epidemiology, Athens University Medical School, Mikras Asias 75, GR- 115 27, Athens, Greece; e-mail:ahatzak@cc.uoa.gr

Manuscript received October 1, 2001; accepted January 16, 2002.

© 2002 Lippincott Williams & Wilkins, Inc.