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Maternal HIV-1 Antibody and Vertical Transmission in Subtype C Virus Infection.

Guevara, Hugo; Casseb, Jorge; Zijenah, Lynn S.; Mbizvo, Michael; Oceguera, Leopoldo F. III; Hanson, Carl V.; Katzenstein, David A.; Hendry, Michael R.
JAIDS Journal of Acquired Immune Deficiency Syndromes: April 15, 2002
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Summary: The role of maternal humoral immune response and viral load was analyzed in relation to the incidence of mother-to-child transmission (MTCT) of infants born to HIV-1 subtype C infected mothers. High levels of viral RNA in the serum correlated with MTCT as did high titers of subtype C consensus V3 peptide binding antibodies (BA) and neutralizing antibody (NA) to subtype B HIV-1MN. Logistic regression analysis showed that maternal viral load and V3 peptide subtype C BA were independent predictors for MTCT, odds ratio (OR) = 2.22 and OR = 2.52, respectively. No correlation between NA to homologous HIV-1 subtype C virus and MTCT was found. BA to V3 peptides may provide a rapid inexpensive method that can be used to determine the risk of HIV-1 MTCT.

(C) 2002 by Lippincott Williams & Wilkins