Skip Navigation LinksHome > April 15, 2002 - Volume 29 - Issue 5 > Maternal HIV-1 Antibody and Vertical Transmission in Subtype...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
Articles: PDF Only

Maternal HIV-1 Antibody and Vertical Transmission in Subtype C Virus Infection.

Guevara, Hugo; Casseb, Jorge; Zijenah, Lynn S.; Mbizvo, Michael; Oceguera, Leopoldo F. III; Hanson, Carl V.; Katzenstein, David A.; Hendry, Michael R.

Collapse Box


Summary: The role of maternal humoral immune response and viral load was analyzed in relation to the incidence of mother-to-child transmission (MTCT) of infants born to HIV-1 subtype C infected mothers. High levels of viral RNA in the serum correlated with MTCT as did high titers of subtype C consensus V3 peptide binding antibodies (BA) and neutralizing antibody (NA) to subtype B HIV-1MN. Logistic regression analysis showed that maternal viral load and V3 peptide subtype C BA were independent predictors for MTCT, odds ratio (OR) = 2.22 and OR = 2.52, respectively. No correlation between NA to homologous HIV-1 subtype C virus and MTCT was found. BA to V3 peptides may provide a rapid inexpensive method that can be used to determine the risk of HIV-1 MTCT.

(C) 2002 by Lippincott Williams & Wilkins


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.