Skip Navigation LinksHome > August 15, 2001 - Volume 27 - Issue 5 > Dendritic Cells Transduced With HIV Nef Express Normal Level...
Text sizing:
A
A
A
JAIDS Journal of Acquired Immune Deficiency Syndromes:
Articles: PDF Only

Dendritic Cells Transduced With HIV Nef Express Normal Levels of HLA-A and HLA-B Class I Molecules.

Cramer, Lorraine A.; Frelinger, Jeffrey A.

Collapse Box

Abstract

Summary: HIV Nef protein is important for viral pathogenesis and disease progression. Nef downregulates CD4 and major histocompatibility antigens on the surface of HIV-infected T cells. HIV also infects dendritic cells. We wanted to determine if Nef had a similar function in professional antigen-presenting cells, where downregulation of Class I could have important effects on the initiation of HIV specific cytolytic T cell responses. We infected human dendritic cells with adenovirus expressing Nef. In contrast to T cells and Hela cells, HLA-A and HLA-B molecules are not downregulated nor are other class I molecules increased. We show that, in dendritic cells, HIV Nef has little effect on CD4 or Class I expression.

(C) 2001 Lippincott Williams & Wilkins, Inc.

Login

Article Tools

Share

Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.