Skip Navigation LinksHome > February 1, 2001 - Volume 26 - Issue 2 > No Increased Human Herpesvirus 8 Seroprevalence in Patients...
JAIDS Journal of Acquired Immune Deficiency Syndromes:
Articles: PDF Only

No Increased Human Herpesvirus 8 Seroprevalence in Patients With HIV-Associated Non-Hodgkin's Lymphoma.

Gérard, Laurence; Agbalika, Félix; Sheldon, Julie; Maillard, Anne; Schulz, Thomas F.; Oksenhendler, Eric

Collapse Box


Summary: Human herpesvirus 8 (HHV-8) is closely associated with Kaposi's sarcoma (KS), HIV-associated Castleman's disease, and primary effusion lymphoma. As a high frequency of non-Hodgkin's lymphoma (NHL) has been reported in patients with HIV-associated KS, we hypothesized that HHV-8 infection could be indirectly implicated in the pathogenesis of NHL. We assessed the prevalence of HHV-8 antibodies in 63 patients with NHL compared with 126 HIV-infected matched control patients without NHL. Serum samples from cases and controls were assayed for antibodies to HHV-8 lytic and latent antigens using an indirect immunofluorescence assay. In patients with concordant serologic results, HHV-8 antibodies were detected in 41.5% of the NHL cases and 37% of the controls. This absence of a significant difference in HHV-8 seroprevalence between cases and controls (p = .73) does not support a possible role for HHV-8 infection in the development of NHL in HIV-infected patients.

(C) 2001 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.