Skip Navigation LinksHome > June 1, 2000 - Volume 24 - Issue 2 > Inverse Correlation of Telomerase Activity/Proliferation of...
Text sizing:
JAIDS Journal of Acquired Immune Deficiency Syndromes:
Articles: PDF Only

Inverse Correlation of Telomerase Activity/Proliferation of CD4+ T Lymphocytes and Disease Progression in Simian Immunodeficiency Virus-Infected Nonhuman Primates.

Bostik, Pavel; Brice, Gary T.; Greenberg, Kenneth P.; Mayne, Ann E.; Villinger, Francois; Lewis, Mark G.; Ansari, Aftab A.

Collapse Box


Summary: Both increased lymphocyte renewal with subsequent exhaustion of the immune system and impaired T-cell renewal have been put forth to account for CD4+ T-cell depletion and development of AIDS in HIV-1-infected humans and SIV-infected nonhuman primates. In the present study, telomeric terminal restriction fragment length and telomerase activity were used as measures of proliferative activity of T lymphocytes from three nonhuman primate species before and after being infected with SIV. In peripheral blood T cells, our data show both species and T-cell-subsetspecific differences in proliferative activity accompanied by different patterns of disease progression. A significant postinfection increase in telomerase/proliferative activity in CD4+ T cells from seropositive sooty mangabeys and from normal progressor rhesus macaques was associated with asymptomatic infection or delayed disease progression, respectively, whereas a decrease in telomerase/proliferative activity detected in CD4+ T cells postinfection from SIVsmmPBj 14-infected pigtailed macaques was associated with rapid CD4+ T-cell depletion and disease progression. The levels of telomerase activity observed in CD4+ T cells from peripheral blood closely parallelled those seen in CD4+ T cells in lymph node samples from selected animals. Our data suggest that an increase in proliferative activity of T lymphocytes in vivo may be associated with a favorable course of SIV infection in nonhuman primates.

(C) 2000 Lippincott Williams & Wilkins, Inc.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.