Skip Navigation LinksHome > December 5, 1995 - Volume 10 - Issue 5 > HIV gp120-Specific Cell-Mediated Immune Responses in Mice Af...
Text sizing:
Journal of Acquired Immune Deficiency Syndromes & Human Retrovirology:

HIV gp120-Specific Cell-Mediated Immune Responses in Mice After Oral Immunization With Recombinant Salmonella.

Berggren, Ruth E.; Wunderlich, Annette; Ziegler, Elizabeth; Schleicher, Mary; Duke, Richard C.; Looney, David; Fang, Ferric C.

Collapse Box


Summary: Salmonella is of great interest as a potential human immunodeficiency virus vaccine vector because of its ability to elicit potent mucosal and systemic immune responses when administered orally. To determine whether such a vaccine could elicit an immune response in mice, plasmids expressing HIV gp120-LAI were introduced into attenuated S. typhimurium. Three serial doses of 1010 recombinant organisms were administered orally to BALB/c mice at 2-week intervals. Immunized mice but not control mice demonstrated proliferative T cell responses to gp120-LAI, comparable in magnitude to the proliferative responses to Salmonella antigens. Immunized mice had detectable serum and intestinal Salmonella-specific IgA and serum Salmonella-specific IgG. However, no gp120-specific antibody was detected in either serum or intestinal washes. These results indicate that live recombinant Salmonella-based vaccine constructs can induce HIV-specific cellular immune responses in vivo.

(C) Lippincott-Raven Publishers.


Article Tools


Article Level Metrics

Search for Similar Articles
You may search for similar articles that contain these same keywords or you may modify the keyword list to augment your search.