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Differences in Participation in Experimental Drug Trials Among Persons With AIDS

Diaz Theresa; Chu, Susan Y.; Sorvillo, Frank; Mokotoff, Eve; Davidson, Arthur J.; Samuel, Michael C.; Herr, Mary; Doyle, Brian; Frederick, Margaret; Fann, Alan S.; Conti, Lisa; Hermann, Pat; Checko, Patricia J.
JAIDS Journal of Acquired Immune Deficiency Syndromes: December 5th, 1995
EPIDEMIOLOGY: PDF Only

Summary:To measure participation in experimental drug trials among persons with acquired immunodeficiency syndrome (AIDS), we interviewed 4,604 persons at least 18 years of age who were reported to have AIDS to 11 state and city health departments in the United States. Ten percent reported that they were currently in a trial. Current enrollment differed significantly (p < 0.05) by race/ethnicity (blacks, 5%; whites, 14%; Hispanics, 15%), gender (women, 7%; men, 11%), exposure mode (injection drug use, 5%, men who have sex with men, 14%), annual household income (<$10,000, 8%, ≥$10,000, 14%), education (<12 years, 6% ≥12 years, 12%), health care (no regular care, 1%, public care, 8%; private care, 17%), and time since AIDS diagnosis (≤6 months, 9%; <6 months, 12%). Adjusting for all factors and time since AIDS diagnosis, blacks (adjusted odds ratio [AOR] = 0.35, 95% confidence interval [CI] 0.26, 0.47), persons with less than 12 years of education (AOR = 0.71, CI 0.53, 0.96), and those without regular health care (AOR = 0.24, CI 0.10, 0.61) remained less likely to be in a trial. Blacks, those with less than 12 years of education, and persons without regular health care were less likely than other persons with AIDS to be currently enrolled in AIDS trials. To increase enrollment of these persons, researchers must address barriers to participation for these groups.

Division of HIV/AIDS, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Public Health Service, U.S. Department of Health and Human Services, Atlanta, Georgia; *Los Angeles County Health Department, Los Angeles, California; †Michigan Department of Public Health, Detroit, Michigan; ‡Denver Department of Health and Hospitals, Denver, Colorado; §New Mexico Department of Health, Albuquerque, New Mexico; ∥Delaware Department of Health, Wilmington, Delaware; ¶Arizona Department of Health, Phoenix, Arizona; **Washington Department of Health, Seattle, Washington; ††Georgia Department of Human Resources, Atlanta, Georgia; ‡‡Florida Department of Health and Rehabilitative Services, Tallahassee, Florida; §§South Carolina Department of Health and Environmental Control, Columbia, South Carolina; ∥∥Connecticut State Department of Health Services, Hartford, Connecticut, U.S.A.

Address correspondence and reprint requests to Dr. Theresa Diaz, Centers for Disease Control and Prevention, 1600 Clifton Road, Mailstop E47, Atlanta, GA 30333, U.S.A.

Manuscript received October 26, 1994; accepted July 12, 1995.

© Lippincott-Raven Publishers.