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A Prospective Study of HIV-Seropositive Asymptomatic Women of Childbearing Age in a Developing Country

DESCHAMPS, MARIE-MARCELLE; PAPE, JEAN W.; DESVARIEUX, MOISE; WILLIAMS-RUSSO, PAMELA; MADHAVAN, SHANTHA; HO, JOHN L.; JOHNSON, WARREN D. Jr.
JAIDS Journal of Acquired Immune Deficiency Syndromes: May 1993
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SummaryAn observational study of 140 HIV-seropositive asymptomatic women of childbearing age was conducted in Haiti from 1984 to 1992 as part of a larger natural history study. Forty-four women were pregnant or became pregnant during the study period. The progression to HIV-related disease, AIDS, and mortality from AIDS was compared in the pregnant and nonpregnant cohorts. The mean follow-up time was 44 months. Overall, 32 of the 140 women (38%) developed AIDS, and 26 (19%) died from AIDS during the study period, with a cumulative AIDS incidence rate of 16% at 3 years after study entry. There was a trend toward earlier manifestation of HIV-related symptoms among the pregnant cohort, but no significant difference was observed in the rate of progression to AIDS or death between the pregnant and nonpregnant women.

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